118460-52-9Relevant academic research and scientific papers
Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation
Dong, Kaiwu,Feng, Sitian,Shen, Chaoren,Tang, Yitian,Yang, Chenjue
, p. 7508 - 7512 (2020/10/09)
Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched α,α-difluoro-β-arylbutanoic esters were prepar
Synthesis of Enantioenriched α,α-Dichloro- and α,α-Difluoro-β-Hydroxy Esters and Amides by Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation
Zheng, Long-Sheng,Phansavath, Phannarath,Ratovelomanana-Vidal, Virginie
, p. 5107 - 5111 (2018/09/13)
A mild and convenient approach was developed to prepare a series of α,α-dihalogeno β-hydroxy esters or amides by using commercially available Noyori's complex [RuCl(p-cymene)(R,R)-TsDPEN] as a catalyst (S/C = 100?200) in the asymmetric transfer hydrogenat
Enantioselective synthesis of 2,2-difluoro-3-hydroxycarboxylates by rhodium-catalyzed hydrogenation
Kuroki,Asada,Iseki
, p. 9853 - 9858 (2007/10/03)
The highly enantioselective synthesis of 2,2-difluoro-3-hydroxycarboxylates has been achieved by hydrogenating 2,2-difluoro-3-oxocarboxylates in the presence of chiral rhodium-(amidephosphine-phosphinite) complexes. Ethyl 4,4,4-trifluoroacetoacetate can be successfully transformed into the enantiomerically enriched 4,4,4-trifluoro-3-hydroxybutanoate in the same manner. (C) 2000 Elsevier Science Ltd.
A convenient method for the preparation of α,α-difluoro-β-ketoesters and α,α-difluoroamides from terpenic and perfumery aldehydes
Watanabe, Shoji,Fujita, Tsutomu,Sakamoto, Masami,Takeda, Hiromichi,Kitazume, Tomoya,Yamazaki, Takashi
, p. 1 - 7 (2007/10/03)
Reformatsky reactions with ethyl bromodifluoroacetate gave α,α-difluoro-β-hydroxyesters in good yield from the corresponding terpenic and perfumery aldehydes. α,α-Difluoro-β-ketoesters were prepared by Swern oxidation of the α,α-difluoro-β-hydroxyesters. The reaction of hydroxyesters with amines in the presence of lipase MY, lipase PS or Novozym 435 gave α,α-difluoroamides.
Oxidation of Fluoroalkyl-Substituted Carbinols by the Dess-Martin Reagent
Linderman, Russell J.,Graves, David M.
, p. 661 - 668 (2007/10/02)
The efficient oxidation of mono-, di-, tri-, and perfluoroalkyl-substituted carbinols has been accommplished by the Dess-Martin periodinane oxidant.A variety of functional groups are compatible with the oxidation procedure.Monitoring the oxidation by 19F NMR indicated that a discreet periodinane intermediate is formed during the course of the reaction.Nonnucleophilic or sterically encumbered α-thiofluoro carbinols were readily oxidized; however, a nucleophilic α-thio-substituted trifluoromethyl carbinol was not.A tert-butyl alcohol modified periodinane oxidant was ultimately employed to achieve oxidation in this example.
