1184635-37-7Relevant academic research and scientific papers
Total synthesis and biological evaluation of methylgerambullone
Moon, Jong Taik,Ha, Sung Hoon,Lee, So Hyung,Kwon, Tae Hui,Oh, Chun Rim,Kim, Young Deuk,Kim, Jungahn,Choo, Dong Joon,Lee, Jae Yeol
scheme or table, p. 52 - 55 (2010/04/24)
First total synthesis of methylgerambullone (MGB, 1) isolated from Glycosmis angustifolia was completed via a convergent route. The effect of MGB on the contractile responses of the isolated guinea-pig ileum induced by acetylcholine was investigated. As a result, it showed a potent relaxation rate (78.66 ± 4.30% at 100 mg/L) in a concentration-dependent manner on longitudinal smooth muscle contraction of isolated guinea-pig ileum induced by 1 μM acetylcholine.
