118466-52-7Relevant academic research and scientific papers
Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L- glutamic acid (GPE) modified at the α-carboxylic acid
Trotter, Nicholas S.,Brimble, Margaret A.,Harris, Paul W.R.,Callis, David J.,Sieg, Frank
, p. 501 - 517 (2007/10/03)
The synthesis of nine GPE* analogues, wherein the α-carboxylic acid group of glutamic acid has been modified, is described by coupling readily accessible N-benzyloxycarbonyl-glycyl-l-proline 2 with various analogues of glutamic acid. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glutamate residue on the observed neuroprotective properties of the endogenous tripeptide GPE.
Synthesis of Casein-Related Peptides and Phosphopeptides. XVI. The Efficient Synthesis of the Casein-Related O-Phosphoseryl-Containing Peptide Ac-Glu-Ser(P)-Leu-Ser(P)-Ser(P)-Ser(P)-Glu-Glu-NHMe
Perich, John W.,Johns, R. B.,Reynolds, Eric C.
, p. 385 - 394 (2007/10/02)
The multiple-O-phosphoseryl-containing peptide, Ac-Glu-Ser(P)-Leu-Ser(P)-Ser(P)-Ser(P)-Glu-Glu-NHMe, was prepared in high yield by the use of Boc-Ser(PO3Ph2)-OH in the Boc mode of peptide synthesis for the preparation of the protected Ser(PO3Ph2)-octapept
The Efficient Synthesis of a Complex O-Phosphoseryl-containing Peptide Ac-Glu-PSer-Leu-PSer-P-Ser-PSer-Glu-Glu-NHMe
Perich, John W.,Johns, R. B.
, p. 664 - 666 (2007/10/02)
The title octapeptide was prepared by the synthesis of the fully protected tetra-Ser(PO3Ph2)-octapeptide by incorporation of Boc-Ser(PO3Ph2)-OH (Boc = t-butoxycarbonyl) in conventional Boc/solution phase peptide synthesis, followed by the complete hydroge
