Welcome to LookChem.com Sign In|Join Free

CAS

  • or

118474-44-5

Post Buying Request

118474-44-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

118474-44-5 Usage

General Description

4,5-Dimethyl-1H-imidazole-2-carboxaldehyde is a chemical compound with the molecular formula C5H7N2O. It is a white solid with a molecular weight of 109.12 g/mol. 4,5-Dimethyl-1H-imidazole-2-carboxaldehyde is widely used in the pharmaceutical industry as an intermediate in the synthesis of various medications. It is also used in organic synthesis and as a building block for the preparation of other chemical compounds. 4,5-Dimethyl-1H-imidazole-2-carboxaldehyde is known for its strong odor and is considered to be a potentially hazardous chemical that should be handled with care.

Check Digit Verification of cas no

The CAS Registry Mumber 118474-44-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,4,7 and 4 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 118474-44:
(8*1)+(7*1)+(6*8)+(5*4)+(4*7)+(3*4)+(2*4)+(1*4)=135
135 % 10 = 5
So 118474-44-5 is a valid CAS Registry Number.

118474-44-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,5-Dimethyl-1H-imidazole-2-carbaldehyde

1.2 Other means of identification

Product number -
Other names QC-4375

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118474-44-5 SDS

118474-44-5Relevant articles and documents

Direct O-Acylation of Small Molecules Containing CO2(1-)---HN<--HO Units by a Distorted Amide: Enhancement of Amine Basicity by a Pendant Carboxylate in a Serine Protease Mimic

Skorey, K. I.,Somayaji, V.,Brown, R. S.

, p. 1445 - 1452 (2007/10/02)

The kinetics of the reaction of two series of amino alcohols (ethanol amines and 2-hydroxymethylimidazoles) with a distorted amide were studied as models for the acylation of the serine proteases.The pH/logk2max profiles plateau above the amine pKa, indicating the basic form is active.In all cases, the reactions proceed by initial O-acylation to produce esters.With primary or secondary ethanolamines, subsequent O-->N acyl transfer occurs to give amides.In each series, a Bronsted relationship exists relating the increasing amine pKa with an increasing second-order rate constant for O-acylation.Amino alcohols containing a pendant carboxylate (e.g., serine and the 4(5)- derivative of 2-hydroxymethylimidazole) fit on the Bronsted plots exactly, which suggests the amine pKa controls the reactivity.The role of the carboxylate is to enhance the amine basicity by electrostatic/inductive means.This is particularly effective in solvents of reduced polarity (40percent and 80percent v/v, EtOH/H2O) since the above effects counteract the normal drop in amine pKa exhibited by the other amino alcohols that do not possess the CO2(1-).Both series exhibit low kinetic solvent isotope effects of between 1 and 2.In the imidazole alcohol series, as the amine pKa increases the kinetic solvent isotope effect tends to 1.0.This is discussed in terms of a possible involvement of direct nucleophilic attack of an ammonium alkoxide zwitterion on 1.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 118474-44-5