1184751-39-0Relevant academic research and scientific papers
Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators
Nishimura, Teruyuki,Iino, Tomoharu,Mitsuya, Morihiro,Bamba, Makoto,Watanabe, Hitomi,Tsukahara, Daisuke,Kamata, Kenji,Sasaki, Kaori,Ohyama, Sumika,Hosaka, Hideka,Futamura, Mayumi,Nagata, Yasufumi,Eiki, Jun-ichi
scheme or table, p. 1357 - 1360 (2009/10/15)
The identification and structure-activity-relationships (SARs) of novel 2-amino benzamide glucokinase activators are described. Compounds in this series were developed to be potent GK activators, and their binding mode to the GK protein was determined by crystal structure analysis. In vivo pharmacokinetic and acute in vivo efficacy studies of compound 18 are also described.
