1184787-15-2Relevant academic research and scientific papers
Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs
Liu, Wujun,Wu, Siguo,Hou, Shuhua,Zhao, Zongbao (Kent)
experimental part, p. 8378 - 8383 (2009/12/28)
Fourteen phosphodiester-type β-nicotinamide adenine dinucleotide (NAD+) analogs were prepared starting from nicotinamide. The phosphodiester linkage was effectively assembled in 69-93% yields via condensation reaction between 2′,3′-di-O-acetyl nicotinamide mononucleotide and alcohols in the presence of 2,4,6-triisopropylbenzenesulfonyl chloride. The analog β-nicotinamide ribose-5-(2-phenylethyl) phosphate showed beneficial effects on cell growth of model microorganisms.
