118482-04-5Relevant academic research and scientific papers
Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process
Chen, Yuan,Xu, Fanghui,Sun, Zhihua
, p. 44421 - 44425 (2017/09/26)
A synthetic approach for 1,2-disubstituted benzimidazoles has been successfully designed based on effective C-N bond construction, which demonstrated mild reaction conditions and excellent yields. The method involves treating derivatives of o-phenylenediamine with tert-butanesulfoxide and NBS under acidic conditions, which undergoes an aza-Wittig-equivalent process to afford the desired products. Using this method, a series of benzimidazoles containing multiple functional groups with varying electronic effects have been successfully constructed.
6-beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof
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, (2008/06/13)
Antibacterial penicillins of the formula STR1 or a pharmaceutically acceptable salt thereof wherein R1 is a heterocyclic group and R is hydrogen, the residue of certian carboxy protecting groups or the residue of an ester group readily hydrolyzable in vivo having activity against resistant organisms.
