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(8)S-HEPE, also known as 8(S)-hydroxyeicosapentaenoic acid, is a specialized pro-resolving mediator (SPM) derived from eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish oil. It plays a crucial role in the resolution of inflammation and the regulation of immune responses, exhibiting anti-inflammatory and pro-resolving effects in various disease models.

118492-81-2

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  • (7R)-7-(2-HYDROXY-2-PHENYLACETYLAMINO)-6-OXO-3-{[1-(SULFOMETHYL)(1,2,3,4-TETRAAZOL-5-YLTHIO)]METHYL}-2H,7H,7AH-AZETIDINO[2,1-B]1,3-THIAZINE-4-CARBOXYLICACID

    Cas No: 118492-81-2

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  • 5,9,11,14,17-Eicosapentaenoicacid, 8-hydroxy-, (5Z,8S,9E,11Z,14Z,17Z)-

    Cas No: 118492-81-2

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118492-81-2 Usage

Uses

Used in Pharmaceutical Industry:
(8)S-HEPE is used as an anti-inflammatory and pro-resolving agent for its ability to promote the clearance of inflammatory cells and the resolution of inflammation, making it a promising therapeutic target for the treatment of inflammatory and immune-mediated disorders.
Used in Arthritis Treatment:
(8)S-HEPE is used as a therapeutic agent for arthritis, where it helps in reducing inflammation and promoting the resolution of the disease.
Used in Colitis Treatment:
(8)S-HEPE is used as a therapeutic agent for colitis, where it exhibits anti-inflammatory effects and contributes to the resolution of the inflammatory process in the colon.
Used in Asthma Treatment:
(8)S-HEPE is used as a therapeutic agent for asthma, where it helps in reducing airway inflammation and improving respiratory function by promoting the resolution of inflammation.

Check Digit Verification of cas no

The CAS Registry Mumber 118492-81-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,4,9 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 118492-81:
(8*1)+(7*1)+(6*8)+(5*4)+(4*9)+(3*2)+(2*8)+(1*1)=142
142 % 10 = 2
So 118492-81-2 is a valid CAS Registry Number.

118492-81-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (8)S-HEPE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:118492-81-2 SDS

118492-81-2Downstream Products

118492-81-2Relevant articles and documents

Synthesis of 8-HEPE and 10-HDoHE in both (R)- and (S)-Forms via Wittig Reactions with COOH-Ylides

Suganuma, Yuta,Saito, Shun,Kobayashi, Yuichi

, p. 338 - 342 (2019)

Wittig reactions using carboxy (CO 2 H) ylides derived from a carboxylic phosphonium salt and NaN(TMS) 2 (NaHMDS) in a 1:1 ratio were applied to the synthesis of 8-HEPE and 10-HDoHE, which are metabolites of eicosapentaenoic acid and

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