1184973-50-9

Basic information

• Product Name: 4-CARBOXYTOLBUTAMIDE-D9
• Synonyms: 4-CARBOXYTOLBUTAMIDE-D9;1-Butyl-d9-3-(p-carboxyphenyl)sulfonylurea;4-[[[(Butyl-d9-amino)carbonyl]amino]sulfonyl]-benzoic Acid;Carboxycarbutamide-d9;p-[(Butyl-d9-carbamoyl)sulfamoyl]-benzoic Acid;Tolbutamide-d9 Carboxylic Acid
• CAS NO: 1184973-50-9
• Molecular Formula: C12H16N2O5S
• Molecular Weight: 300.33084
• Product Categories: Intermediates & Fine Chemicals;Isotope Labeled Compounds;Metabolites & Impurities;Pharmaceuticals;Isotope Labelled Compounds
• Mol File: 1184973-50-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: >3000C (dec)
• Appearance: /
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 4-CARBOXYTOLBUTAMIDE-D9(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CARBOXYTOLBUTAMIDE-D9(1184973-50-9)
• EPA Substance Registry System: 4-CARBOXYTOLBUTAMIDE-D9(1184973-50-9)

Safety Data

• Hazardous Substances Data: 1184973-50-9(Hazardous Substances Data)

Usage

Description

4-CARBOXYTOLBUTAMIDE-D9 is a labeled metabolite of Tolbutamide, which is a medication used to treat type 2 diabetes. It is formed by the cytochrome CYP2C8 and CYP2C9 subfamily of P450 enzymes. 4-CARBOXYTOLBUTAMIDE-D9 is characterized by its off-white powder appearance.

Uses

Used in Pharmaceutical Industry:
4-CARBOXYTOLBUTAMIDE-D9 is used as a labeled metabolite for the study and analysis of Tolbutamide's metabolism. It aids in understanding the role of cytochrome P450 enzymes, specifically CYP2C8 and CYP2C9, in the metabolic process of Tolbutamide.
Used in Research and Development:
In the field of research and development, 4-CARBOXYTOLBUTAMIDE-D9 serves as a valuable tool for investigating the metabolic pathways and enzyme interactions related to Tolbutamide. This can contribute to the development of new drugs or the improvement of existing ones, particularly for the treatment of type 2 diabetes.
Used in Quality Control:
4-CARBOXYTOLBUTAMIDE-D9 is also utilized in the quality control of Tolbutamide products to ensure their purity, potency, and consistency. By monitoring the presence and concentration of this labeled metabolite, manufacturers can maintain high standards for the drug's production and distribution.
Used in Drug Metabolism Studies:
In the field of drug metabolism, 4-CARBOXYTOLBUTAMIDE-D9 is employed as a reference compound to study the activity and specificity of cytochrome P450 enzymes. This helps researchers understand how these enzymes process various drugs and contribute to drug-drug interactions, which is crucial for optimizing drug therapies and minimizing adverse effects.