118514-67-3Relevant academic research and scientific papers
Synthesis of (±)-camptothecin using a [3+2] nitrone cycloaddition to construct the CDE ring moiety
Yu, Jurong,Depue, Jeffrey,Kronenthal, David
, p. 7247 - 7250 (2004)
A novel synthesis to camptothecin is described. A Friedlander condensation of o-aminobenzaldehye with tricylclic ketone affords camptothecin after further elaboration. Tricyclic ketone is prepared via a route employing a [3+2] nitrone cycloaddition and an intramolecular Knoevenagel condensation. A novel synthesis to camptothecin is described. A Friedlander condensation of o-aminobenzaldehye 2 with tricylclic ketone 3 affords camptothecin after further elaboration. Tricyclic ketone 3 is prepared via a route employing a [3+2] nitrone cycloaddition and an intramolecular Knoevenagel condensation.
