118515-48-3

Usage

InChI:InChI=1/C12H15N5O5/c1-21-11-7-6(13-4-16-11)10(15-3-14-7)17-12-9(20)8(19)5(2-18)22-12/h3-5,8-9,12,18-20H,2H2,1H3,(H,14,15,17)

Upstream product

• 118515-47-2 4-methoxy-8-<(2,3-O-isopropylidene-β-D-ribofuranosyl)amino>pyrimido<5,4-d>pyrimidine 
• 32980-71-5 2,4,6,8-Tetrachloro-pyrimido[5,4-d]pyrimidine 
• 51172-55-5 p-toluenesulfonate d'amino-1, O-isopropylidene-2',3', α,β-D-ribofurannose 
• 118515-46-1 4-methoxy-8-<(2,3-O-isopropylidene-β-D-ribofuranosyl)amino>-2,6-dichloropyrimido<5,4-d>pyrimidine 
• 118515-38-1 2,4,6-trichloro-8-<(2,3-O-isopropylidene-β-D-ribofuranosyl)amino>pyrimido<5,4-d>pyrimidine 

Relevant academic research and scientific papers

Substituted pyrimido[5,4-d]pyrimidine nucleosides

α and β-ribonucleosides of substituted pyrimido[5,4-d]pyrimidines are used in treating malignant tumors in vivo. A novel synthesis for preparing these compounds and other related compounds is further disclosed.

Antitumor and antiviral activity of synthetic α- and β-ribonucleosides of certain substituted pyrimido[5,4-d]pyrimidines: a new synthetic strategy for exocyclic aminonucleosides

A novel and direct synthesis of the antiviral and antitumor agent 4-amino-8-(β-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine (ARPP, 8) and its α-anomer (11) has been developed. Treatment of 2,4,6,8-tetrachloro-pyrimido[5,4-d]pyrimidine (1) with 2,3-O-iso