1185198-42-8

Basic information

• Product Name: N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-serine benzyl ester
• Synonyms: N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-serine benzyl ester
• CAS NO: 1185198-42-8
• Molecular Weight: 528.995
• Mol File: 1185198-42-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-serine benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-serine benzyl ester(1185198-42-8)
• EPA Substance Registry System: N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-serine benzyl ester(1185198-42-8)

Safety Data

• Hazardous Substances Data: 1185198-42-8(Hazardous Substances Data)

Upstream product

• 1185198-27-9 N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine 
• 1738-80-3 L-serine benzyl ester p-toluenesulfonate hydrochoride 
• 1738-72-3 L-serine benzyl ester 

Downstream Products

• 1185198-62-2 N-(2-chloro-9H-purin-6-yl)-N-cyclopropylglycyl-L-serine benzyl ester 

Relevant articles and documents

A class of novel conjugates of substituted purine and Gly-AA-OBzl: Synthesis and evaluation of orally analgesic activity

Aimed at the chemotherapy of chronic pain two kinds of analgesic pharmacophores, substituted purine and Gly-AA-OBzl, were coupled via a five-step-reaction procedure and 19 novel conjugates N-[2-chloro-9- (tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycylamino acid benzylesters were provided. On mouse-tail flick model their in vivo analgesic activities were assayed. The results indicate that introducing Gly-OC2H 5 into the 6-position of the substituted purine leads to ambiguous increase of the analgesic activity, while introducing Gly-AA-OBzl into this position leads to significant increase of the analgesic activity.