118520-82-4

Basic information

• Product Name: 4-bromo-3-(4-chlorophenyl)-1H-isochromen-1-one
• Synonyms: 4-bromo-3-(4-chlorophenyl)-1H-isochromen-1-one
• CAS NO: 118520-82-4
• Molecular Weight: 335.584
• Mol File: 118520-82-4.mol

Chemical Properties

• CAS DataBase Reference: 4-bromo-3-(4-chlorophenyl)-1H-isochromen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-3-(4-chlorophenyl)-1H-isochromen-1-one(118520-82-4)
• EPA Substance Registry System: 4-bromo-3-(4-chlorophenyl)-1H-isochromen-1-one(118520-82-4)

Safety Data

• Hazardous Substances Data: 118520-82-4(Hazardous Substances Data)

Upstream product

• 118520-71-1 2-(2-(4-chlorophenyl)ethynyl)benzoic acid methyl ester 

Relevant articles and documents

Regioselective Synthesis of 4-Aryl-1,3-dihydroxy-2-naphthoates through 1,2-Aryl-Migrative Ring Rearrangement Reaction and their Photoluminescence Properties

4-Aryl-1,3-dihydroxy-2-naphthoates having the less accessible 1,2,3,4-tetrasubstituted naphthalene scaffold and that show photoluminescence emission from solid state as well as in solutions, were selectively synthesized from brominated lactol silyl ethers

Synthesis of benzil-o-carboxylate derivatives and isocoumarins through neighboring ester-participating bromocyclizations of o-alkynylbenzoates

Bromide mediated neighboring ester-participating bromocyclizations of o-alkynylbenzoates are described here for the synthesis of benzil-o-carboxylates. 4-bromoisocoumarins are also synthesized when phenyl o-alkynylbenzoate is used as the substrate. Mechanistic studies suggest that the whole process is composed of an electrophilic bromocyclization and a dibromohydration-based ring-opening, and the neighboring ester group participates in the bromocyclization. Interestingly, the two oxygen atoms of the keto carbonyls in benzil-o-carboxylates are both derived from water. The electrophilic bromo source is in situ generated from the oxidation of bromide.

Organomercury Mediated Synthesis of Isocoumarins

A facile and convenient synthesis of isocoumarins via an organomercurial route is reported.The synthesis involves reaction of methyl 2-alkynbenzoates with mercuric acetate to give the corresponding isocoumarin mercurials which serve as intermediates to afford the appropriate isocoumarins having substituents as Cl,I,Br,COCH3 etc.