1185240-22-5

Basic information

• Product Name: A77 1726-D4
• Synonyms: A77 1726-D4;N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide-d4, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide-d4, LEF-M-d4;TeriflunoMide-d4;TeriflunoMide-D4/ FlucyaMide-D4 / A77 1726-D4;Leflunomide-d4 Metabolite (Teriflunomide-d4)
• CAS NO: 1185240-22-5
• Molecular Formula: C12H9F3N2O2
• Molecular Weight: 270.2072696
• Product Categories: Isotope Labeled Compounds;Metabolites & Impurities;Tyrosine Kinase Inhibitors;Isotope Labelled Compounds
• Mol File: 1185240-22-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 214-217°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• CAS DataBase Reference: A77 1726-D4(CAS DataBase Reference)
• NIST Chemistry Reference: A77 1726-D4(1185240-22-5)
• EPA Substance Registry System: A77 1726-D4(1185240-22-5)

Safety Data

• RIDADR: UN 1648 3 / PGII
• Hazardous Substances Data: 1185240-22-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 1185240-22-5 differently. You can refer to the following data:
1. As the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug, Teriflunomide-d4 can be used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function
2. Teriflunomide-d4 can be intended for use as an internal standard for the quantification of Leflunomide metabolite by GC- or LC-mass spectrometry.

General Description

This stable-labeled internal standard of teriflunomide is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays. Teriflunomide, also known as Aubagio, is the active metabolite of leflunomide, an immunosuppressive disease-modifying antirheumatic drug, used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis.