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CAS

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1185256-03-4

2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil, also known as Candesartan Cilexetil EP Impurity D, is a chemical compound that serves as an impurity in the pharmaceutical drug Candesartan Cilexetil. It is characterized by its white solid appearance.

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  • 1185256-03-4 Structure

  • Basic information

    1. Product Name: 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil
    2. Synonyms: 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil;Candesartan Cilexetil N2-Ethyl AMide (2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil);3-[[2'-(2-Ethyl-2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-2,3-dihydro-2-oxo-1H-benzimidazole-4-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;(RS)-1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl-3-[[2'- (2-ethyl-2H-tetrazol-5-yl)-4-biphenylyl]Methyl]-2-oxo-2,3-dihydro-1H-benziMidazole-4-carboxylate;2-Hydroxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-BenziMidazole-7-carboxylic Acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl Ester;Candesartan Cilexetil IMpurity D;Candesartan Cilexetil EP IMpurity D;Candesartan Impurity 5
    3. CAS NO:1185256-03-4
    4. Molecular Formula: C33H34N6O6
    5. Molecular Weight: 610.65966
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 1185256-03-4.mol

  • Chemical Properties

    1. Melting Point: 169-171?C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.38
    6. Refractive Index: N/A
    7. Storage Temp.: Refrigerator
    8. Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
    9. PKA: 11.24±0.30(Predicted)
    10. CAS DataBase Reference: 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil(1185256-03-4)
    12. EPA Substance Registry System: 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil(1185256-03-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1185256-03-4(Hazardous Substances Data)

1185256-03-4 Usage

Uses

Used in Pharmaceutical Industry:
2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil is used as an impurity in the production of Candesartan Cilexetil, a medication used for treating hypertension and heart failure. Its presence is monitored and controlled to ensure the quality and safety of the final drug product.

Check Digit Verification of cas no

The CAS Registry Mumber 1185256-03-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,5,2,5 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1185256-03:
(9*1)+(8*1)+(7*8)+(6*5)+(5*2)+(4*5)+(3*6)+(2*0)+(1*3)=154
154 % 10 = 4
So 1185256-03-4 is a valid CAS Registry Number.

1185256-03-4 Well-known Company Product Price

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  • USP

  • (1087847)  Candesartan cilexetil Related Compound D  United States Pharmacopeia (USP) Reference Standard

  • 1185256-03-4

  • 1087847-10MG

  • 14,500.98CNY

  • Detail

1185256-03-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil

1.2 Other means of identification

Product number -
Other names 1-cyclohexyloxycarbonyloxyethyl 3-[[4-[2-(2-ethyltetrazol-5-yl)phenyl]phenyl]methyl]-2-oxo-1H-benzimidazole-4-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1185256-03-4 SDS

1185256-03-4Downstream Products

1185256-03-4Relevant articles and documents

Identification, synthesis and structural determination of some impurities of candesartan cilexetil

Havllcek, Jaroslav,Mandelova, Zuzana,Weisemann, Ruediger,Strelec, Ivo,Placek, Lukas,Radl, Stanislav

, p. 347 - 362 (2009)

All principal candesartan cilexetil impurities and/or degradation products were synthesized and identified. The differentiation of N-l and N-2 ethylated candesartan cilexetil derivatives was performed using ID and 2D NMR experiments. The influence of the magnetic field on the resolution and sensitivity of NMR experiments is shown. Selective hydrolysis of these compounds then provided corresponding producrs of hydrolysis of the ethoxy group. Institute of Organic Chemistry and Biochemistry.

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