118526-19-5

Basic information

• Product Name: 5-Benzothiazolol,2-amino-(9CI)
• Synonyms: 5-Benzothiazolol,2-amino-(9CI);2-aminobenzo[d]thiazol-5-ol;2-Amino-5-hydroxybenzothiazole;2-Amino-5-hydroxy-1,3-benzothiazole;2-Amino-1,3-benzothiazol-5-ol;5-hydroxy-1,3-benzothiazol-2-amine
• CAS NO: 118526-19-5
• Molecular Formula: C₇H₆N₂OS
• Molecular Weight: 166.2
• Product Categories: BENZOTHIAZOLE;Building Blocks
• Mol File: 118526-19-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 187 °C(Solv: water (7732-18-5))
• Boiling Point: 394.6°C at 760 mmHg
• Flash Point: 192.4°C
• Appearance: /
• Density: 1.553g/cm³
• Vapor Pressure: 8.61E-07mmHg at 25°C
• Refractive Index: 1.823
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.43±0.40(Predicted)
• CAS DataBase Reference: 5-Benzothiazolol,2-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzothiazolol,2-amino-(9CI)(118526-19-5)
• EPA Substance Registry System: 5-Benzothiazolol,2-amino-(9CI)(118526-19-5)

Safety Data

• Hazardous Substances Data: 118526-19-5(Hazardous Substances Data)

Usage

General Description

5-Benzothiazolol,2-amino-(9CI) is a chemical compound that belongs to the class of benzothiazoles. It is a yellow to brown solid with a molecular formula of C7H6N2S. 5-Benzothiazolol,2-amino-(9CI) is commonly used in the synthesis of various pharmaceuticals and agrochemicals. It has been studied for its potential use in anti-inflammatory, analgesic, and antifungal applications. Additionally, 5-Benzothiazolol,2-amino-(9CI) has been investigated for its potential use as a fluorescent probe in bioimaging and as a corrosion inhibitor in the field of materials science. It is important to handle this compound with care and to follow safety protocols when working with it in a laboratory setting.

InChI:InChI=1/C7H6N2OS/c8-7-9-5-3-4(10)1-2-6(5)11-7/h1-3,10H,(H2,8,9)

Upstream product

• 536-90-3 m-Anisidine 
• 37014-08-7 3-methoxyphenylthiourea 
• 54346-87-1 2-amino-5-methoxybenzothiazole 
• 51-81-0 3-aminophenol hydrochloride 
• 3394-05-6 N-(3-hydroxyphenyl)thiourea 
• 136-95-8 2-amino-benzthiazole 

Downstream Products

• 1309261-59-3 3-(5-hydroxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4(3H)-one 
• 1309261-72-0 C₂₁H₁₄N₄O₂S 
• 1191251-67-8 2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-6-ol 

Relevant articles and documents

Neurodegenerative Therapies

The present invention provides a compound of formula (I) wherein: Y represents a C or N atom which may be substituted or form a cyclic group with R′″ but may not be a quaternary C atom; R′ is —OR1, —CONH2, —CF3, F, —OH, —NO2, —CN or —OCOR1 in which R1, is C1-3 alkyl and each may be in the beta or gamma position; R″ is C1-3 alkyl or H; and R′″ is H or a group consisting of 1-12 non-hydrogen atoms and may be linear, branched and/or incorporate one or more cyclic groups, cyclic groups may be aromatic and/or heterocyclic and 2 or more cyclic groups may be linked or fused and each may be substituted; or a salt, hydrate or solvate of a compound of formula (I) for use in the treatment or prevention of a neurodegenerative disorder by inhibiting formation of neurofibrillary (tau) tangles and/or by inhibiting Dyrk 1A. The invention further relates to non-therapeutic uses of these compounds.

QSAR modeling of synthesized 3-(1,3-benzothiazol-2-yl) 2-phenyl quinazolin-4(3H)-ones as potent antibacterial agents

Present communication elicits the designing and synthesis of 3-(1,3-benzothiazol-2-yl) 2-phenyl quinazolin-4(3H)-ones as potential antibacterial agents. A number of substituted 2-amino benzothiazoles, 2-amino-5-[(E)-phenyl diazenyl] benzoic acid, and 2-phenyl-4H benzo[d] [1,3] oxazin-4-one were synthesized as the precursor substrates. The compounds were synthesized in excellent yields and the structures were corroborated on the basis of IR, 1H NMR, Mass, and elemental analysis data. These compounds were screened in vitro for their antibacterial activity against a representative panel of Gram positive and Gram negative bacteria and models were generated through quantitative structure-activity relationship (QSAR).The activity contributions due to structural and substituent effects were determined using sequential regression procedure. The antimicrobial assay data show that the synthesized compounds are found to manifest profound antimicrobial activity. Springer Science+Business Media, LLC 2011.

An efficient facile and selective hydroxylation of nitrogen heterocycles

Nitrogen heterocycles have been efficiently hydroxylated under mild and neutral conditions by employing Cupric nitrate/phosphate buffer/30%hydrogen peroxide system. The present method afforded the biologically active and important hydroxy heterocycles. Th