118528-62-4Relevant articles and documents
Direct observation of adsorption kinetics on clays by cation-π interaction-triggered aggregation luminescence
Zhong, Jinpan,Cui, Xingyu,Guan, Weijiang,Lu, Chao
, p. 13218 - 13224 (2018)
Luminescence quenching of organic molecules in an aggregation state has become a long-standing challenge for further imaging applications. Inspired by recent research on cation-π interaction triggered luminescence, we designed and synthesized an organic cation, E-4-formyl-styryl-pyridinium salt (FSPH), with strong fluorescent emission in the aggregation state. The formation of the FSPH dimer replaces weaker π-π interactions with stronger cation-π interactions to trigger the aggregation luminescence. The excellent optical performances of FSPH in the aggregation state show promise in elucidating the adsorption kinetics of clays because the aggregation of adsorbates during clay adsorption is inevitable. Expectedly, the complete adsorption kinetics of FSPH on clays was visualized by virtue of an in situ fluorescence imaging technique. The subsequent fluorescence intensity quantification revealed that the adsorption kinetics of FPSH on clays could be divided into three stages: molecular aggregation at the edge, formation of a block layer, and molecular invasion from the edge to the center. The discovery of the formation of a block layer not only identifies a previously unknown source of the lower adsorption capacity with larger particle sizes of clays, but also inspires the great passion of scientists to study the adsorption kinetics of other adsorbents by employing cation-π interaction-triggered aggregation luminescence.
Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation
Liu, Hao,Chen, Li,Zhou, Fei,Zhang, Yun-Xiao,Xu, Ji,Xu, Meng,Bai, Su-Ping
supporting information, p. 3089 - 3096 (2019/06/14)
Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable molecule ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The molecule is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.
A-pi-A' compounds, and preparation method and application thereof
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Paragraph 0023; 0024, (2017/08/31)
The invention discloses A-pi-A' compounds, and a preparation method and an application thereof. The structure of the compounds is represented by formula (I) or formula (II), the compounds of the formula (I) are chemically called as 2-(1E)-2-[4-(1H-imidazo
