1185295-59-3Relevant academic research and scientific papers
Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury
MacNevin, Christopher J.,Atif, Fahim,Sayeed, Iqbal,Stein, Donald G.,Liotta, Dennis C.
, p. 6012 - 6023 (2009)
Preclinical and clinical research findings have revealed that the hormone progesterone, when acutely administered, can dramatically reduce cerebral edema, inflammation, tissue necrosis, and programmed cell death following traumatic brain injury (TBI). The poor aqueous solubility of progesterone, however, limits its potential use as a therapeutic. Several chemically novel analogues of progesterone and its natural metabolite allopregnanolone have been synthesized and screened using both in vitro and whole animal models of TBI. The new derivatives demonstrated greatly improved solubility and select compounds have shown equivalent effectiveness to progesterone in reducing cerebral edema after TBI. 2009 American Chemical Society.
STEROID ANALOGUES FOR NEUROPROTECTION
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Page/Page column 99; 102, (2009/10/21)
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.
