1185301-26-1

Basic information

• Product Name: BOC-3-AMINOADIPIC ACID
• Synonyms: BOC-3-AMINOADIPIC ACID
• CAS NO: 1185301-26-1
• Molecular Formula: C11H19NO6
• Molecular Weight: 261.27
• Mol File: 1185301-26-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BOC-3-AMINOADIPIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-3-AMINOADIPIC ACID(1185301-26-1)
• EPA Substance Registry System: BOC-3-AMINOADIPIC ACID(1185301-26-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1185301-26-1(Hazardous Substances Data)

Upstream product

• 4771-80-6 1,2,5,6-tetrahydrobenzoic acid 
• 135262-85-0 4-(tert-butoxycarbonylamino)-1-cyclohexene 
• 854102-62-8 [(S,E)-1-benzyl-3-phenylallyl]carbamic acid tert-butyl ester 
• 72155-45-4 Boc-L-phenylalaninal 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 854102-54-8 [(R)-1-benzyl-3-phenylpropyl]carbamic acid tert-butyl ester 
• 197006-13-6 (R)-N-t-butoxycarbonyl-5-benzyloxycarbonylmethyl-2-pyrrolidinone 

Relevant articles and documents

Preparation method of beta-homoglutamic acid

The invention belongs to the field of preparation of organic compounds, and provides a preparation method of beta-homoglutamic acid. The method is characterized in that: 3-cyclohexenecarboxylic acid is used as a raw material, beta-homoglutamic acid is synthesized at a high yield through three the steps of reactions of Curtius rearrangement, olefin oxidation and protection group removal, and beta-homoglutamic acid with high yield and high optical purity can be obtained through configuration retention by using optically pure 3-cyclohexenecarboxylic acid. The method has the advantages of easily available raw materials, mild reaction conditions and low cost, and is suitable for large-scale preparation of beta-homoglutamic acid.

Facile stereoselective synthesis of γ-substituted γ-amino acids from the corresponding α-amino acids

A facile stereoselective method for the synthesis of γ-substituted, γ-amino acids from α-amino acids was developed. The key step of the procedure is complete reduction of the keto functionality of α-amino acyl Meldrum's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid undergoes thermal decarboxylative ring closure to a 5-substituted pyrrolidinone which yields the corresponding γ-amino acid after basic hydrolysis. The overall yield of the procedure ranges from 40 to 65%.