1185309-41-4Relevant academic research and scientific papers
Chiral VAPOL Imidodiphosphoric Acid-Catalyzed Asymmetric Vinylogous Mannich Reaction for the Synthesis of Butenolides
Zhou, Tianyun,Gao, Jigang,Liu, Guofeng,Guan, Xukai,An, Dong,Zhang, Suoqin,Zhang, Guangliang
supporting information, p. 2006 - 2010 (2018/09/18)
Chiral butenolides were synthesized by the enantioselective vinylogous Mannich reaction. Chiral (VAPOL)-type imidodiphosphoric acids are efficient catalysts for the asymmetric vinylogous Mannich (AVM) reaction of aldimines and trimethylsiloxyfuran in toluene. Under the optimized conditions, a series of butenolides were obtained with high yields (up to 98%) and enantioselectivities (up to 97% ee) as well as excellent diastereoselectivities (up to 99:1 dr).
The application of chiral phosphine-Schiff base type ligands in silver(I)-catalyzed asymmetric vinylogous Mannich reaction of aldimines with trimethylsiloxyfuran
Yuan, Zhi-Liang,Jiang, Jia-Jun,Shi, Min
supporting information; experimental part, p. 6001 - 6007 (2011/03/17)
Catalytic asymmetric vinylogous Mannich (AVM) reactions of readily available aldimines with trimethylsiloxyfuran in the presence of catalytic amount of AgOAc and chiral phosphine-Schiff base type ligands are described, affording the corresponding products in up to 91% yield, anti/syn >99:1 and 81% ee.
