118533-06-5

Upstream product

• 6979-94-8 2',3',5'-tri-O-acetyl-guanosine 
• 49757-42-8 4,4',4''-trimethoxytrityl chloride 
• 123154-89-2 Acetic acid (3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 118533-05-4 5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine 

Downstream Products

• 118573-14-1 S,S-diphenyl N²-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate 
• 118533-04-3 2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)-7-methylguanosine-5'-diphosphate 
• 118573-15-2 S-phenyl N²-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethylene-7-methylguanosine 5'-phosphorothioate 

Relevant academic research and scientific papers

Synthesis of Capped Oligoribonucleotides by Use of Protected 7-Methylguanosine 5'-Diphosphate Derivatives

This paper describes the capping reaction of 5'-phosphorylated oligoribonucleotides protected only by a tetrahydropyranyl group at each 2'-position.By use of the conventional capping agent PhSppm7GTMTrmM, m7G5pppGUA and m7G5'pppGUAUUA were synthesized from the corresponding oligoribonucleotide 5'-monophosphate derivatives.Since the latter was obtained in low yield because of poor solubility of the partially protected pUUA in DMF, the oligomer component was converted into a phosphorimidazolidate species which was found to be soluble in DMF and allowed to react with a newly designed capping agent, ppm7GTMTrmM.This triphosphate bond formation proceeded smoothly to give m7G5'pppGUAUUA in good yield.