118544-67-5

Upstream product

• 108-24-7 acetic anhydride 
• 781577-65-9 (S)-4-Amino-3-oxo-5-phenyl-pentanenitrile 
• 139168-56-2 (Z)-(S)-4-Acetylamino-2-cyano-3-hydroxy-5-phenyl-pent-2-enoic acid tert-butyl ester 
• 118544-55-1 ((S)-1-Benzyl-3-cyano-2-oxo-propyl)-carbamic acid tert-butyl ester 
• 118544-47-1 ((Z)-(S)-1-Benzyl-3-cyano-2-pyrrolidin-1-yl-allyl)-carbamic acid tert-butyl ester 
• 88815-92-3 1-(thio-t-Boc-α-aminophenylalanyl)-azacyclopentane 
• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 

Downstream Products

• 139168-75-5 N-((E)-(S)-1-Benzyl-3-cyano-5-hydroxy-4-methyl-2-oxo-hex-3-enyl)-acetamide 
• 139168-70-0 N-((S)-1-Benzyl-3-cyano-3-cyclohexylidene-2-oxo-propyl)-acetamide 
• 139168-73-3 N-((E)-(S)-1-Benzyl-3-cyano-5-hydroxy-4-methyl-2-oxo-pent-3-enyl)-acetamide 
• 139168-71-1 N-((S)-1-Benzyl-3-cyano-3-cyclopentylidene-2-oxo-propyl)-acetamide 
• 139168-68-6 2-((E)-(S)-4-Acetylamino-2-cyano-3-oxo-5-phenyl-pent-1-enyl)-benzoic acid 
• 139168-72-2 N-((S)-1-Benzyl-3-cyano-4-methyl-2-oxo-pent-3-enyl)-acetamide 
• 139168-66-4 N-[(E)-(S)-1-Benzyl-3-cyano-4-(4-dimethylamino-phenyl)-2-oxo-but-3-enyl]-acetamide 
• 139168-69-7 N-[(E)-(S)-1-Benzyl-3-cyano-4-(4-hydroxy-3-methoxy-phenyl)-2-oxo-but-3-enyl]-acetamide 
• 139168-64-2 N-[(E)-(S)-1-Benzyl-3-cyano-4-(4-methoxy-phenyl)-2-oxo-but-3-enyl]-acetamide 
• 139168-65-3 N-((E)-(S)-1-Benzyl-3-cyano-2-oxo-4-phenyl-but-3-enyl)-acetamide 
• 139168-67-5 N-[(E)-(S)-1-Benzyl-3-cyano-4-(4-nitro-phenyl)-2-oxo-but-3-enyl]-acetamide 

Relevant academic research and scientific papers

Silica-Gel-Catalysed Knoevenagel Condensation of Peptidyl Cyanomethyl Ketones with Aromatic Aldehydes and Ketones. A Novel Michael Acceptor Functionality for C-Modified Peptides: The Benzylidene and Alkylidene Cyanomethyl Ketone Function

Simple preparation of cyanomethyl ketone derivatives 5a-5b of N-acetylphenylalanine and N-acetylleucylphenylalanine is accomplished by condensation of the corresponding activated carboxylic acids 3a-3b and the carbanion of tert-butyl cyanoacetate to give

CARBOXYL-MODIFIED AMINO ACIDS AND PEPTIDES: I) AN EFFICIENT METHOD FOR THE SYNTHESIS OF MONOFUNCTIONALIZED ENAMINES AND MONOFUNCTIONALIZED METHYL KETONE DERIVATIVES FROM THIOAMIDES VIA EPISULFIDES AND THIOIMINIUM SALTS

Thioamides 4 were transformed by two convenient routes to various functionalized enamines 7 containing different electron-withdrawing groups E which on subsequent hydrolysis gave the corresponding methyl ketone derivatives 8.Application of this methodology to obtain modified dipeptides at the carboxyl end, the determination of stereochemistry and the degree of racemization are discussed.