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1185503-38-1

1185503-38-1

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1185503-38-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1185503-38-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,5,5,0 and 3 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1185503-38:
(9*1)+(8*1)+(7*8)+(6*5)+(5*5)+(4*0)+(3*3)+(2*3)+(1*8)=151
151 % 10 = 1
So 1185503-38-1 is a valid CAS Registry Number.

1185503-38-1Downstream Products

1185503-38-1Relevant articles and documents

Optimization of piperidin-4-yl-urea-containing melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Reducing hERG-associated liabilities

Berglund, Susanne,Egner, Bryan J.,Graden, Henrik,Graden, Joakim,Morgan, David G.A.,Inghardt, Tord,Giordanetto, Fabrizio

scheme or table, p. 4274 - 4279 (2010/04/26)

The discovery and optimization of piperidin-4-yl-urea derivatives as MCH-R1 antagonists is herein described. Previous work around the piperidin-4-yl-amides led to the discovery of potent MCH-R1 antagonists. However, high affinity towards the hERG potassium channel proved to be an issue. Different strategies to increase hERG selectivity were implemented and resulted in the identification of piperidin-4-yl-urea compounds as potent MCH-R1 antagonists with minimized hERG inhibition.

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