118552-54-8Relevant academic research and scientific papers
Phospholipase A2 inhibitors
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, (2008/06/13)
There are disclosed compounds of the formula STR1 wherein R1 is lower alkyl, lower alkoxycarbonyl lower alkyl, aralkoxycarbonyl, aralkoxycarbonyl lower alkyl or indol-2-yllower alkyl; R2 is hydrogen, lower alkyl or biphenylyl lower alkylcarbonyl; or R1 and R2 taken together form a 5- or 6-membered saturated heterocyclic ring; R3 is hydrogen or lower alkyl; R4 is alkyl of 10-20 carbon atoms, cycloalkyl of 10-20 carbon atoms or phenylalkyl of 10-16 carbon atoms; or R3 and R4 taken are decahydroisoquinolin-2-yl, 3,5-dimethylpiperazin-1-yl or 3,3,5-trimethylhexahydroazepin-1-yl; or a pharmaceutically acceptable salt thereof, and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivities and various inflammatory conditions.
