118554-31-7Relevant academic research and scientific papers
Allenes. Part 47. Pyridopyrimidines and their Hydrolysis Products from Allenic and Acetylenic Nitriles
Landor, Stephen R.,Landor, Phyllis D.,Johnson, Andrew,Fomum, Z. Tanee,Mbafor, J. Tanyi,Nkengfack, A. Ephraim
, p. 975 - 980 (2007/10/02)
The reactions between 2-aminopyridine, C-substituted 2-aminopyridines, and allenic nitriles or phenylpropynenitrile give, initially, 2-amino-2H-pyridopyrimidines which are moderately stable under acidic conditions but undergo addition of water with extreme ease under basic conditions to form 4-hydroxypyridopyrimidines.These undergo ring cleavage when refluxed in ethanol to pyridyl ketones (5).
