1185730-50-0Relevant articles and documents
Cyclic caged morpholinos: Conformationally gated probes of embryonic gene function
Yamazoe, Sayumi,Shestopalov, Ilya A.,Provost, Elayne,Leach, Steven D.,Chen, James K.
, p. 6908 - 6911 (2012/10/08)
Feeling a bit cagey: Morpholino-based antisense reagents have been caged through oligonucleotide cyclization (see scheme), enabling photocontrol of gene expression in zebrafish embryos and larvae. Using these reagents, the timing of exocrine cell fate commitment in the developing pancreas has been examined. Copyright
Photocleavable linker methods and compositions
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Page/Page column 33; 34, (2011/04/25)
Bifunctional linkers are provided that comprise a photocleavable moiety flanked by two different amine reactive moieties. In some embodiments the photocleavable moiety is a dimethoxynitrobenzyl moiety. In other embodiments the photocleavable moiety is 8-b
Versatile synthesis and rational design of caged morpholinos
Ouyang, Xiaohu,Shestopalov, Ilya A.,Sinha, Surajit,Zheng, Genhua,Pitt, Cameron L. W.,Li, Wen-Hong,Olson, Andrew J.,Chen, James K.
supporting information; experimental part, p. 13255 - 13269 (2010/01/30)
Embryogenesis is regulated by genetic programs that are dynamically executed in a stereotypic manner, and deciphering these molecular mechanisms requires the ability to control embryonic gene function with similar spatial and temporal precision. Chemical