118575-70-5

Upstream product

• 2243-53-0 trans-styrylacetic acid 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 90172-76-2 (E)-1-Diazo-5-phenyl-pent-4-en-2-one 
• 118575-48-7 (2E)-2,4-pentadienyl 4-phenyl-3-butenoate 
• 118575-47-6 (2E,4Z)-2,4-hexadienyl 4-phenyl-3-butenoate 
• 118575-46-5 (2E,4E)-2,4-hexadienyl 4-phenyl-3-butenoate 
• 152978-77-3 (2S)-1-methoxy-1-oxo-2-propyl (E)-4-phenyl-3-butenoate 
• 152978-84-2 (2S)-1-(N,N-dimethylamino)-1-oxo-2-propanyl (E)-4-phenyl-3-butenoate 
• 152978-78-4 (+/-)-1-methoxy-1-oxo-3-butyl (E)-4-phenyl-3-butenoate 
• 118597-17-4 (2Z)-4-methyl-2,4-pentadienyl 4-phenyl-3-butenoate 
• 118575-49-8 (3E)-3,5-hexadienyl 4-phenyl-3-butenoate 
• 152978-79-5 (2S)-1-methoxy-1-oxo-2-phenyl-2-ethyl (E)-4-phenyl-3-butenoate 
• 118575-66-9 1-(2-phenylethenyl)-6-(2-propenyl)-3-oxabicyclo<3.1.0>hexan-2-one 
• 118575-65-8 (3aα,7α)-(+/-)-3,3a,6,7-tetrahydro-5-methyl-7-phenyl-1H-cycloheptafuran-1-one 
• 118575-50-1 (2E)-4-methyl-2,4-pentadienyl 4-phenyl-3-butenoate 
• 118575-53-4 (5-methyl-2-furanyl)methyl 4-phenyl-3-butenoate 

Relevant academic research and scientific papers

A Concise, metathesis based approach to construction of the lepadiformine/cylindricine tricyclic framework

A tandem dienyne metathesis based strategy has been developed for construction of the core tricyclic framework found in the lepadiformine and cylindricine alkaloids. 2-Pentenyl-2-ethynylpyrollidine acrylamide that serves as the starting material for the k

Modular Cyclopentenone Synthesis through the Catalytic Molecular Shuffling of Unsaturated Acid Chlorides and Alkynes

We describe a general strategy for the intermolecular synthesis of polysubstituted cyclopentenones using palladium catalysis. Overall, this reaction is achieved via a molecular shuffling process involving an alkyne, an α,β-unsaturated acid chloride, which serves as both the alkene and carbon monoxide source, and a hydrosilane to create three new C-C bonds. This new carbon monoxide-free pathway delivers the products with excellent yields. Furthermore, the regioselectivity is complementary to conventional methods for cyclopentenone synthesis. In addition, a set of regio- and chemodivergent reactions are presented to emphasize the synthetic potential of this novel strategy.

Stereoselective α-Tertiary Alkylation of N -(Arylacetyl)oxazolidinones

A method has been developed for the α-tertiary alkylation of zirconium enolates of N -(arylacetyl)oxazolidinones. This reaction directly installs an all-carbon quaternary center vicinal to a benzylic tertiary carbon in a highly diastereoselective manner.

Ni-Catalyzed Regiodivergent and Stereoselective Hydroalkylation of Acyclic Branched Dienes with Unstabilized C(sp3) Nucleophiles

Two complementary regiodivergent [(P,N)Ni]-catalyzed hydroalkylations of branched dienes are reported. When amides are employed as unstabilized C(sp3) nucleophiles, a highly regioselective 1,4-addition process is favored. The addition products are obtained in high yield and with excellent stereocontrol of the internal olefin. With use of a chiral ligand and imides as carbon nucleophiles, a 3,4-addition protocol was developed, enabling construction of two contiguous tertiary stereocenters in a single step with moderate to high levels of diastereocontrol and excellent enantiocontrol. Both methods operate under mild reaction conditions, display a broad scope, and show excellent functional group tolerance. The synthetic potential of the 3,4-hydroalkylation reaction was established via a series of postcatalytic modifications.

Direct Enantioselective and Regioselective Alkylation of β,γ-Unsaturated Carboxylic Acids with Chiral Lithium Amides as Traceless Auxiliaries

Efficient asymmetric alkylation of β,γ-unsaturated carboxylic acids without prior functionalization is enabled by chiral lithium amides. Enantioselectivity is imparted by a putative mixed lithium amide-enediolate aggregate that acts a traceless auxiliary formed in situ, allowing for a direct asymmetric alkylation and a simple recovery of the chiral reagent.

Histone Deacetylase Inhibitors

This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).

HISTONE DEACETYLASE INHIBITORS

This invention relates to generally inhibiting histone deacetylase (HDAC) enzymes (e.g., HDAC1, HDAC2, and HDAC3).

New preparation of (Z)-1-phenyl-3-cyano-2-propen-1-ones

Reaction of γ-phenyl-β,γ-unsaturated hydroxamates with bis(collidine)-bromine(I) hexafluorophosphate led to the formation of cyclic bromo imidates. Reaction of these with triethylamine led to the formation of 3-cyano-2-propen-1-ones with good yields by a

Photoinduced cleavage of N-N bonds of aromatic hydrazines and hydrazides by visible light

A photocatalytic system involving [Ru(bpyrz)(PFH, visible light, and air has been developed for cleavage of the N-N bonds of hydrazines and hydrazides. This catalytic system is generally effective for N,N-disubstituted hydrazine and hydrazide derivatives, including arylhydrazides, N-alkyl-N-arylhydrazines, and N,N-diarylhydrazines. The utility of this cleavage reaction has been demonstrated by synthesizing a variety of secondary aromatic amines. Georg Thieme Verlag Stuttgart ? New York.

Preparation of imino lactones by electrophilic cyclization of β,γ-unsaturated hydroxamates: Formation of 3-cyanoprop-2-en-1-ones through fragmentation reactions

Treatment of γ-disubstituted β,γ-unsaturated hydroxamates with bis(collidine)bromine(I) hexafluorophosphate led mainly to the formation of cyclic bromo imidates - the thermodynamic products. Unsaturated cyclic imidates were then obtained by treatment with