1185763-40-9Relevant academic research and scientific papers
METHOD FOR DETECTING AMYLOID AGGREGATES USING STYRYLPYRIDAZINE-ONE DERIVATIVES
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Paragraph 0093; 0094, (2014/05/20)
The present invention relates to a composition for detecting beta amyloid aggregates and a composition for diagnosing beta amyloid aggregation disease, comprising a 2-styrilpyridizine-3(2H)-one derivative or its pharmaceutically acceptable salt, to a diagnostic kit for diagnosing beta amyloid aggregation disease comprising said composition and to a method for detecting beta amyloid aggregates using said compositions to provide information for beta amyloid aggregation disease diagnosis.
Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer's disease
Park, Yong Dae,Park, Jeong Hoon,Hur, Min Goo,Kim, Sang Wook,Min, Jung-Joon,Park, Seung-Hwan,Yoo, Yung Joon,Yoon, Yong-Jin,Yang, Seung Dae
scheme or table, p. 4106 - 4110 (2012/07/03)
Amyloid plaques, which are primarily composed of aggregated amyloid-beta (Aβ) peptide, are the neuropathological hallmarks of Alzheimer's disease (AD). Fluorescent markers containing 2-styrylpyridazin-3(2H)-ones were developed to detect intracellular aggregated Aβ peptides. Nine compounds exhibited a greater than 10-fold increase of in emission spectra before and after mixing with Aβ aggregates compared with before mixing. Among these compounds, compound 9n exhibited the highest affinity for Aβ aggregates (Kd = 1.84 μM) and selectively stained both aggregated intracellular Aβ and Aβ plaques in the transgenic AD model mice (APP/PS1). These preliminary results indicate that 2-styrylpyridazin-3(2H)-one derivatives are promising alternative fluorescence imaging agent for the study of AD.
