1185844-90-9Relevant academic research and scientific papers
The identification of a series of novel, soluble non-peptidic neuropeptide y Y2 receptor antagonists
Lunniss, Gillian E.,Barnes, Ashley A.,Barton, Nick,Biagetti, Matteo,Bianchi, Federica,Blowers, Stephen M.,Caberlotto, Laura L.,Emmons, Amanda,Holmes, Ian P.,Montanari, Dino,Norris, Roz,Puckey, Gemma V.,Walters, Dewi J.,Watson, Steve P.,Willis, John
, p. 7341 - 7344 (2010)
The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.
The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists
Lunniss, Gillian E.,Barnes, Ashley A.,Barton, Nick,Biagetti, Matteo,Bianchi, Federica,Blowers, Stephen M.,Caberlotto, Laura,Emmons, Amanda,Holmes, Ian P.,Montanari, Dino,Norris, Ros,Walters, Dewi J.,Watson, Steve P.
scheme or table, p. 4022 - 4025 (2010/03/30)
A novel small molecule NPY Y2 antagonist (3) identified from high throughput screening is described. A subsequent SAR study and optimisation programme based around this molecule is also described, leading to the identification of potent and soluble pyridyl analogue 36.
