118587-22-7

Basic information

• Product Name: 3-ethyl 5-methyl 2-({[2-(formylamino)ethyl]sulfanyl}methyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: BBR 2160;2-[[[2-(Formylamino)ethyl]thio]methyl]-1,4-dihydro-6-methyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester
• CAS NO: 118587-22-7
• Molecular Formula: C₂₁H₂₅N₃O₇S
• Molecular Weight: 463.5041
• Mol File: 118587-22-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 655.8°C at 760 mmHg
• Flash Point: 350.4°C
• Density: 1.289g/cm³
• Vapor Pressure: 4.47E-17mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 3-ethyl 5-methyl 2-({[2-(formylamino)ethyl]sulfanyl}methyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethyl 5-methyl 2-({[2-(formylamino)ethyl]sulfanyl}methyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate(118587-22-7)
• EPA Substance Registry System: 3-ethyl 5-methyl 2-({[2-(formylamino)ethyl]sulfanyl}methyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate(118587-22-7)

Safety Data

• Hazardous Substances Data: 118587-22-7(Hazardous Substances Data)

Upstream product

• 39562-17-9 methyl 2-(3-nitrophenylmethylene)acetoacetate 

Relevant articles and documents

2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them

Compounds of formula I, and pharmaceutical compositions containing compounds of formula I STR1 wherein: R1 is: (a) COCH3, COC6 H5, CN or NO2 ; (b) COORa wherein Ra is hydrogen, or optionally substituted C1 -C6 straight or branched alkyl; R2 is optionally substituted phenyl; pentafluorophenyl; α- or β-naphthyl; a five- or six-membered heterocyclic ring; α-benzo[2,3-b]-1,4-dioxan-α-yl; or α-benzofuroxanyl; R3 is COORa; P is hydrogen, --(CH2)p --W, or C1 -C8 linear or branched alkyl; N--P1 is the residue of a primary or secondary amino group wherein P1 is hydrogen, C1 -C6 lower linear or branched alkyl group, or --(CH2)p --W; and P, taken together with P1 and the nitrogen atom to which P1 is linked, may form a pyrrolidine or a piperidine ring; W is hydroxymethyl, formyloxymethyl, CO2 R wherein R is hydrogen or C1 -C4 lower alkyl, CN, saturated or unsaturated heterocyclic ring, C3 -C7 cycloalkyl ring, or optionally substituted phenyl; m is an integer from 1 to 3; n is zero or an integer from 1 to 2; p is zero or an integer from 1 to 3. The compounds of formula (I) and compositions containing them are effective in anti-hypertensive therapy.