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1185908-30-8

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1185908-30-8 Usage

General Description

The chemical known as (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide is a hydrazine derivative with a thioamide functional group. It is commonly used in organic synthesis and pharmaceutical research due to its potential biological activities, including antimicrobial and antitumor properties. The compound has also been studied for its potential use in the treatment of various diseases and conditions. Its chemical structure consists of a phenyl group attached to a hydrazine and thioamide moiety, with a hydroxybenzylidene group linked to the hydrazine nitrogen in an E-configuration. This chemical has a range of potential applications in the fields of medicine, pharmacology, and biochemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 1185908-30-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,5,9,0 and 8 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1185908-30:
(9*1)+(8*1)+(7*8)+(6*5)+(5*9)+(4*0)+(3*8)+(2*3)+(1*0)=178
178 % 10 = 8
So 1185908-30-8 is a valid CAS Registry Number.

1185908-30-8Relevant articles and documents

Synthesis, spectral and structural studies of zinc(II) complexes of salicylaldehyde N(4)-phenylthiosemicarbazone

Seena,Kurup, M.R. Prathapachandra

, p. 726 - 732 (2008)

Five Zn(II) complexes of salicylaldehyde N(4)-phenylthiosemicarbazone (H2L) have been synthesized and physicochemically characterized. Out of the five Zn(II) complexes, one is binuclear {[(ZnL)2]·3C2H5OH (1)} an

Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents

Bo-Wang,He, Zhang-Xu,Li, Yi-Han,Liu, Hong-Min,Ma, Li-Ying,Ma, Qin,Tao, Yuan-Yuan,Wang, Hao-Jie,Wu, Hui-Pan,Zhang, Xin-Hui,Zhao, Bing

, (2020/05/19)

In this paper, a series of thiosemicarbazone derivatives containing different aromatic heterocyclic groups were synthesized and the tridentate donor system of the lead compound was optimized. Most of the target compounds showed improved antiproliferative activity against MGC803 cells. SAR studies revealed that compound 5d displayed significant advantages in inhibition effect with an IC50 value of 0.031 μM, and better selectivity between cancer and normal cells than 3-AP and DpC (about 15- and 5-fold improved respectively). Besides, compound 5d showed selective antiproliferative activity in not only other cancer cells but also different gastric cancer cell lines. In-depth mechanism studies showed that compound 5d could induce mitochondria-related apoptosis which might be related to the elevation of intracellular ROS level, and cause cell cycle arrest at S phase. Moreover, 5d could evidently suppress the cell migration and invasion by blocking the EMT (epithelial–mesenchymal transition) process. Consequently, our studies provided a lead optimization strategy of thiosemicarbazone derivatives which would contribute to discover high-efficiency and low-toxicity agents for the treatment of gastric cancer.

Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural properties, DNA interactions and antiproliferative activity

Dilovic, Ivica,Rubcic, Mirta,Vrdoljak, Visnja,Pavelic, Sandra Kraljevic,Kralj, Marijeta,Piantanida, Ivo,Cindric, Marina

, p. 5189 - 5198 (2008/12/20)

The paper describes synthesis of several novel thiosemicarbazone derivatives. Furthermore, crystal and molecular structure of 4-diethylamino-salicylaldehyde 4-phenylthiosemicarbazone revealed planarity of conjugated aromatic system, which suggested the po

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