1186014-25-4

Upstream product

• 536-40-3 4-chlorobenzoic acid hydrazide 
• 63857-85-2 2-mercapto-5-(4'-chlorophenyl)-1,3,4-thiadiazole 
• 90-02-8 salicylaldehyde 
• 59758-31-5 2-(4-chloro-phenyl)-5-hydrazino-[1,3,4]thiadiazole 

Downstream Products

• 1643532-38-0 C₃₀H₂₄Cl₂N₈O₄S₂Zn 

Relevant academic research and scientific papers

Synthesis and spectral characterization of Zn(II) microsphere series for antimicrobial application

Microsphere series have been synthesized by reacting zinc(II) acetate dihydrate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole/oxadiazole/triazole with salicylaldehyde. Elemental analysis suggests that the complexes have 1:2 and 1:1 stoichiometry of the type [Zn(L)2(H2O)2] and [Zn(L′)(H 2O)2]; LH = Schiff bases derived from 2-hydrazino-5- [substituted phenyl]-1,3,4-thia/oxadiazole with salicylaldehyde; L′H 2 = Schiff bases derived from 3-(substituted phenyl)-4-amino-5- hydrazino-1,2,4-triazole and salicylaldehyde and were characterized by elemental analyses, IR, 1H NMR and 13C NMR spectral data. Scanning electron microscopy (SEM) showed that synthesized materials have microsphere like structure and there EDX analysis comparably matches with elemental analysis. For the antimicrobial application Schiff bases and their zinc(II) complexes were screened for four bacteria e.g. Bacillus subtilis, Pseudomonas aeruginosa, Salmonella typhi, Streptococcus pyogenes and four fungi e.g. Cyrtomium falcatum, Aspergillus niger, Fusarium oxysporium and Curvularia pallescence by the reported method. Schiff base and Zn(II) compounds showed significant antimicrobial activities. However, activities increase upon chelation. Thermal analysis (TGA) data of compound (10) showed its stability up to 300 °C.