1186044-25-6Relevant articles and documents
Highly enantioselective michael addition of malonate derivatives to enones catalyzed by an N,N'-dioxide-scandium(III) complex
Chen, Donghui,Chen, Zhenling,Xiao, Xiao,Yang, Zhigang,Lin, Lili,Liu, Xiaohua,Feng, Xiaoming
supporting information; experimental part, p. 6807 - 6810 (2010/02/28)
A highly enantioselective Michael addition of malonate derivatives to chalcone derivatives catalyzed by L-Ramipril acid derived N,N'-dioxide-scandium (III) complex was reported. The experiment included use of L-Ramipril acid derived N,N'-dioxide L1-nickle(II) complex to catalyze the asymmetric Michael addition of diethyl malonate to chalcone in EtOH at 35°C. The results show that 4 A molecular sieves when added as additives result in an improved reactivity and a 95% yield without loss of enantioselectivity. Diisopropyl malonate is found to be an excellent Michael donor than the reaction accomplished in 15hr in 98% yield with 99% ee. The results also show that the electronic nature or the position of the substituents at the aromatic rings of R2 or 3 has little influence on the enantioselectivity.
