1186050-58-7

Basic information

• Product Name: 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid
• Synonyms: 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid;6-(2H-1,2,3-Triazole-2-yl)-fluorobenzoicacid
• CAS NO: 1186050-58-7
• Molecular Formula: C₉H₆FN₃O₂
• Molecular Weight: 207.1612432
• Mol File: 1186050-58-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 410.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.49±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.00±0.36(Predicted)
• CAS DataBase Reference: 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid(1186050-58-7)
• EPA Substance Registry System: 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid(1186050-58-7)

Safety Data

• Hazardous Substances Data: 1186050-58-7(Hazardous Substances Data)

Usage

General Description

2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid is a chemical compound with a molecular formula C9H5FN3O2. It contains a fluorine atom and a 1,2,3-triazol-2-yl group attached to a benzoic acid molecule. 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid is commonly used in organic synthesis and medicinal chemistry as a building block for the preparation of pharmaceuticals and other biologically active molecules. It is known for its potential antimicrobial, antifungal, and antiviral properties, and its unique structure makes it a valuable tool for drug discovery and development. Additionally, it may also have applications in materials science and catalysis due to its diverse chemical reactivity and potential for forming new molecular architectures.

Upstream product

• 124-38-9 carbon dioxide 
• 111771-08-5 2-fluoro-6-iodobenzoic acid 
• 288-36-8 1 ,2,3-Triazole 

Downstream Products

• 1293284-63-5 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)(hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)methanone 
• 1293283-00-7 2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid 
• 1293286-18-6 methyl 2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl )hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl)pyrimidine-5-carboxylate 
• 1293282-91-3 6-[5-{[2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-2-methylpyrimidin-4(3H)-one 
• 1293281-49-8 [5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone 
• 1293941-03-3 [(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]methanone 
• 1293940-76-7 tert-butyl (1S,6R)-8-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate 
• 1293286-15-3 2-fluoro-6-(2Η-1,2,3-triazol-2-yl)benzoyl chloride 
• 1293280-44-0 4-[5-{[2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-6-methoxy-N,N-dimethylpyrimidin-2-amine 
• 1293280-46-2 6-[5-{[2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-N,N-dimethyl-2-(trifluoromethyl)pyrimidin-4-amine 

Relevant articles and documents

IMPROVED SYNTHETIC METHODS OF MAKING (2H-1,2,3-TRIAZOL-2-YL)PHENYL COMPOUNDS AS OREXIN RECEPTOR MODULATORS

Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-l,2,3-triazol-2- yl)phenyl)methanone are described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia and depression.

Octahydropyrrolo[3,4-c]pyrrole derivatives and use thereof

The invention relates to octahydropyrrolo[3,4-c]pyrrole derivatives and a use thereof. The above compounds and a medicinal composition containing the compounds are used for suppressing an orexin receptor. The invention also relates to a method for preparing the compounds and the medicinal composition, and the use of the compounds and the medicinal composition in the treatment or prevention of orexin receptor related diseases.

Octahydropyrrole[3, 4-c]pyrrole derivative and using method and application thereof

The invention relates to an ctahydropyrrole[3, 4-c]pyrrole derivative and a using method and application thereof. A compound and a drug composition containing the same are used for resisting orexin receptors. The invention further relates to methods of pr