1186073-56-2

Basic information

• Product Name: (E)-3-benzo[1,3]dioxol-5-yl-N-[4-methyl-3-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]acrylamide
• CAS NO: 1186073-56-2
• Molecular Weight: 451.484
• Mol File: 1186073-56-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-benzo[1,3]dioxol-5-yl-N-[4-methyl-3-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-benzo[1,3]dioxol-5-yl-N-[4-methyl-3-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]acrylamide(1186073-56-2)
• EPA Substance Registry System: (E)-3-benzo[1,3]dioxol-5-yl-N-[4-methyl-3-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]acrylamide(1186073-56-2)

Safety Data

• Hazardous Substances Data: 1186073-56-2(Hazardous Substances Data)

Upstream product

• 96249-87-5 3-benzo[1,3]dioxol-5-yl-acryloyl chloride 
• 152460-10-1 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine 

Relevant articles and documents

Design and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells

A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)phenyl]acrylamide( 12d) was the most effective cell growth inhibitor and was 3-fold more potent than STI-571.