1186099-34-2Relevant academic research and scientific papers
Polypeptide dendrimers: Self-assembly and drug delivery
Xu, Xianghui,Li, Caixia,Li, Haiping,Liu, Rong,Jiang, Chao,Wu, Yao,He, Bin,Gu, Zhongwei
experimental part, p. 326 - 333 (2012/01/15)
Amphiphilic dendritic poly(glutamic acid)-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly(glutamic acid) as the macroinitiator in the ring-opening polymerization of NCA-Phe. The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly(glutamic acid) segments as shell. The biocompatibility of the micelles was studied. The release of the anticancer drug doxorubicin from the micelles was investigated in vitro. The results showed that the sustaining release of the drug could last for 60 h. The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells, 75% cancer cells were killed under appropriate in vitro incubation.
