1186121-01-6Relevant academic research and scientific papers
Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors
Shi, Yan,Zhang, Jing,Shi, Mengxiao,O'Connor, Stephen P.,Bisaha, Sharon N.,Li, Chi,Sitkoff, Doree,Pudzianowski, Andrew T.,Chong, Saeho,Klei, Herbert E.,Kish, Kevin,Yanchunas Jr., Joseph,Liu, Eddie C.-K.,Hartl, Karen S.,Seiler, Steve M.,Steinbacher, Thomas E.,Schumacher, William A.,Atwal, Karnail S.,Stein, Philip D.
scheme or table, p. 4034 - 4041 (2010/04/02)
The N,N′-disubstituted cyanoguanidine is an excellent bioisostere of the thiourea and ketene aminal functional groups. We report the design and synthesis of a novel class of cyanoguanidine-based lactam derivatives as potent and orally active FXa inhibitor
