118617-20-2Relevant academic research and scientific papers
Structural elucidation of novel degradation product of brotizolam
Sugimoto, Yoshinori,Kugimiya, Aya,Yoshimura, Yoshifumi,Naoki, Hideo
, p. 3515 - 3518 (2013/06/27)
When the drug product of brotizolam (1) is decomposed according to the interview form and patent, hydrolysate (2) is obtained, but its physicochemical data are still missing. To elucidate the structure based on a spectroscopic approach, the above-mentione
Acid Catalyzed Hydrolysis of Brotizolam, A Thienotriazolodiazepine: Spectroscopic Study
Gallo, B.,Alonso, R. M.,Lete, E.,Badia, M. D.,Patriarche, G. J.,Gelbcke, M.
, p. 867 - 869 (2007/10/02)
The acid catalyzed hydrolysis of the thienotriazolodiazepine, Brotizolam, 2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thienotriazolodiazepine (1), has been studied spectrometrically (ir, pmr, cmr, and ms).The cleavage reaction of the azomethine bond is reversible and the open-ring compound is in equilibrium with the ring closed compound (protonated form of the parent drug).
