118618-94-3Relevant academic research and scientific papers
The structure of 4-benzoyl-5-methyl-2-phenylpyrazol-3-one oxime and its methyl derivatives
Holzer, Wolfgang,Hahn, Katharina,Brehmer, Thomas,Claramunt, Rosa M.,Perez-Torralba, Marta
, p. 1209 - 1219 (2003)
1H and 13C NMR spectroscopic investigations of 4-benzoyl-5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one oxime (4) and different methylation products thereof (5-11) indicate that 4 exists predominantly as 4-enaminopyrazolone in [D6]DMSO solution. Single-crystal X-ray analysis revealed that in the solid state the same tautomeric structure of 4 was present, and closely resembles that of the corresponding N-methylamino product (6). Both compounds are stabilised by an intramolecular hydrogen bond between the pyrazolone C=O group and the N-OH proton. A 1,2-dihydro-3H-pyrazol-3-one structure was found in a clathrate of O-methyloxime 5 and dichloromethane. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
Spiro-fused (C2)-azirino-(C4)-pyrazolones, a new heterocyclic system. Synthesis, spectroscopic studies and X-ray structure analysis
Holzer, Wolfgang,Claramunt, Rosa M.,Perez-Torralba, Marta,Guggi, Davide,Brehmer, Thomas H.
, p. 7943 - 7950 (2007/10/03)
Reaction of 1-substituted 4-acyl-5-hydroxy-3-methyl-1H-pyrazoles (2) with hydroxylamine gives the corresponding "oximes" 3, which are mainly present as (Z)-2,4-dihydro-4-[(hydroxyamino)methylene]-3H-pyrazol-3-ones. Treatment of compounds 3 with trichloroa
