1186189-28-5

Basic information

• Product Name: ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate
• Synonyms: ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate;ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylat;ETHYL 2,4-DIHYDROXY-1,8-NAPHTHYRIDINE-3-CARBOXYLATE
• CAS NO: 1186189-28-5
• Molecular Formula: C₁₁H₁₀N₂O₄
• Molecular Weight: 234.2081
• Mol File: 1186189-28-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 388.1±52.0 °C(Predicted)
• Appearance: /
• Density: 1.46±0.1 g/cm3(Predicted)
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate(1186189-28-5)
• EPA Substance Registry System: ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate(1186189-28-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1186189-28-5(Hazardous Substances Data)

Usage

General Description

Ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate is a chemical compound with the molecular formula C13H11NO5. It is a derivative of the naphthyridine class of compounds and contains a hydroxy group, a carbonyl group, and an ethyl ester group. ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate has potential pharmacological properties and has been studied for its potential application in the development of new drugs. It is a synthetic compound and is not naturally occurring. Its specific uses and applications are still being researched, and it may have potential in the pharmaceutical industry for the treatment of various medical conditions.

Upstream product

• 14667-47-1 methyl 2-aminonicotinate 
• 105-53-3 diethyl malonate 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 3809-93-6 2-Methyl-4H-pyrido<2,3-d><3,1>oxazin-4-one 

Downstream Products

• 847775-07-9 N-cyclohexyl-1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide 
• 1375112-51-8 N-cyclohexyl-1-(p-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide 
• 1375112-63-2 N-cyclohexyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide 

Relevant articles and documents

CANNABINOID RECEPTOR TYPE 2 (CB2) MODULATORS AND USES THEREOF

Disclosed herein are compounds, compositions, and methods for modulating the Cannabinoid receptor 2 (CB2) with the compounds and compositions disclosed herein. Also described are methods of treating diseases or conditions that are mediated by the action of Cannabinoid receptor 2 (CB2) or that we benefit from modulating the Cannabinoid receptor 2 (CB2).

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold

CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Using our previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characterized by different central cores, were synthesized and tested for their affinity toward the human CB1 and CB2 cannabinoid receptors. The obtained results suggest that the new series of quinolin-2(1H)-on-3-carboxamides, 4-hydroxy-2-oxo-1,2-dihydro- 1,8-naphthyridine-3-carboxamides and 1,2-dihydro-2-oxopyridine-3-carboxamides represent novel scaffolds very suitable for the development of promising CB2 ligands. Furthermore, the newly synthesized CB2 ligands inhibit proliferation of several cancer cell lines. In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels.