1186196-20-2Relevant academic research and scientific papers
Synthesis and evaluation of 3″- and 4″-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000
Raju, Ravinder,Castillo, Bernard F.,Richardson, Stewart K.,Thakur, Meena,Severins, Ryan,Kronenberg, Mitchell,Howell, Amy R.
supporting information; experimental part, p. 4122 - 4125 (2010/04/29)
Four 3″- and 4″-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the 1.4 hybridoma only the 4″-fluoro analog led to the production of significant levels of IL-2.
