1186220-05-2Relevant academic research and scientific papers
Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands
Yongye, Austin B.,Appel, Jon R.,Giulianotti, Marc A.,Dooley, Colette T.,Medina-Franco, Jose L.,Nefzi, Adel,Houghten, Richard A.,Martinez-Mayorga, Karina
, p. 5583 - 5597 (2009)
Opioid receptors are important targets for pain management. Here, we report the synthesis and biological evaluation of three positional scanning combinatorial libraries, consisting of linear triamines and piperazines. A highly potent (14 nM) and selective
