1186288-90-3

Upstream product

• 13599-12-7 ethyl 3-phenyl-1H-pyrazole-5-carboxylate 

Downstream Products

• 1321970-22-2 (2S,3R,4S,5R)-2-((1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carbonyl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1488425-83-7 [1-(4-tert-butylbenzyl)-3-phenyl-1H-pyrazol-5-yl][4-(3-methoxyphenyl)piperazin-1-yl]methanone 
• 1488425-82-6 [1-(4-tert-butylbenzyl)-3-phenyl-1H-pyrazol-5-yl][4-(4-fluorophenyl)piperazin-1-yl]methanone 
• 1488425-81-5 [1-(4-tert-butylbenzyl)-3-phenyl-1H-pyrazol-5-yl][4-(2-fluorophenyl)piperazin-1-yl]methanone 
• 1488425-80-4 [1-(4-tert-butylbenzyl)-3-phenyl-1H-pyrazol-5-yl](4-phenylpiperazin-1-yl)methanone 
• 1431618-10-8 1-(4-(tert-butyl)benzyl)-N-(4-methoxyphenyl)-3-phenyl-1H-pyrazole-5-carboxamide 
• 1431618-09-5 1-(4-(tert-butyl)benzyl)-N-(4-ethoxyphenyl)-3-phenyl-1H-pyrazole-5-carboxamide 
• 1431618-08-4 N-(4-bromophenyl)-1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamide 
• 1431618-07-3 1-(4-(tert-butyl)benzyl)-N-(4-chlorophenyl)-3-phenyl-1H-pyrazole-5-carboxamide 
• 1412886-07-7 (S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate 
• 1412886-06-6 ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)acetate 
• 1191284-74-8 C₂₁H₂₁ClN₂O 

Relevant academic research and scientific papers

Synthesis and antifungal activity of novel (1-arylmethyl-3-aryl-1Hpyrazol- 5-yl)(4-arylpiperazin-1-yl)methanone derivatives

A series of novel (1-arylmethyl-3-aryl-1H-pyrazol-5-yl)(4-arylpiperazin-1- yl)methanone derivatives were synthesised. Preliminary study of the structure-activity relationship revealed that 4-chlorophenyl, 4-tert-butylphenyl, 4-fluorophenyl and 3-methoxyphenyl had a promising effect on the antifungal activity.

Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells

A series of novel pyrazole peptidomimetics was synthesized from 3-aryl-1-arylmethyl-1H-pyrazole-5-carboxylic acid and amino acid ester. Structures of the compounds were characterized by means of IR, 1H NMR and mass spectroscopy. Compounds 5e and 5k suppress effectively the growth of A549 lung cancer cells. Preliminary research on the mechanism of action showed that the inhibition might perform through combination of apoptosis, autophagy and cell cycle arrest.

Synthesis and discovery of novel pyrazole carboxamide derivatives as potential osteogenesis inducers

A series of novel N-aryl-3-aryl-1-arylmethyl-1H-pyrazole-5-carboxamide derivatives 4a-l was synthesized by the reaction of 3-aryl-1-arylmethyl-1H- pyrazole-5-carbonyl chloride with substituted aniline in good to excellent yields. Structures of the compoun

Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells

A series of novel 3-aryl-1-arylmethyl-1H-pyrazole-5-carboxamide derivatives 3a-l, were synthesized by the reaction of 3-aryl-1-arylmethyl-1H-pyrazole-5-carbonyl chloride with substituted amine in excellent yields. The compounds 3e-h could suppress A549 lu