1186292-93-2Relevant academic research and scientific papers
Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway
Dessole, Gabriella,Branca, Danila,Ferrigno, Federica,Kinzel, Olaf,Muraglia, Ester,Palumbi, Maria Cecilia,Rowley, Michael,Serafini, Sergio,Steinkuehler, Christian,Jones, Philip
scheme or table, p. 4191 - 4195 (2010/04/24)
We report the synthesis and biological evaluation of N-[(1-aryl-1H-indazol-5-yl)methyl]amide derivatives as Smoothened antagonists and inhibitors of the Hedgehog pathway. Identification of the lead structure 1 by HTS, followed by SAR study on the amide and aryl portions led to the discovery of antagonists with nanomolar activity.
