1186299-71-7 Usage
Classification
Imidazole compound This compound is classified as an imidazole derivative due to the presence of the imidazole ring in its structure.
Tert-butoxycarbonyl groups
Two The structure of this compound features two tert-butoxycarbonyl groups, which are responsible for its protective properties in organic synthesis.
Use as a protecting group
Amines 2-(tert-butoxycarbonyl)amino-1-(tert-butoxycarbonyl)-1H-imidazole is commonly used in organic synthesis to protect amine functional groups from unwanted reactions.
Precursor for synthesis
Pharmaceutical and organic compounds This compound can act as a precursor for the synthesis of various pharmaceuticals and organic compounds, making it a valuable building block in chemical research.
Importance in medicinal chemistry
Drug development and research Due to its potential applications in drug development and research, 2-(tert-butoxycarbonyl)amino-1-(tert-butoxycarbonyl)-1H-imidazole holds significant importance in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1186299-71-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,6,2,9 and 9 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1186299-71:
(9*1)+(8*1)+(7*8)+(6*6)+(5*2)+(4*9)+(3*9)+(2*7)+(1*1)=197
197 % 10 = 7
So 1186299-71-7 is a valid CAS Registry Number.
1186299-71-7Relevant articles and documents
Design, synthesis, and evaluation of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives as Aurora kinase inhibitors
Jeong, Yunkyung,Lee, Jooyeon,Ryu, Jae-Sang
supporting information, p. 2114 - 2124 (2016/04/20)
A series of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives were designed, synthesized, and evaluated for the Aurora kinase inhibitory activities. The novel hinge-binder tethered 1,2,3-triazolylsalicylamide scaffold was effectively assembled by Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). A variety of alkynes with hinge binders were used to search proper structures-binding relationship to the hinge region. The synthesized 1,2,3-triazolylsalicylamide derivatives showed significant Aurora kinase inhibitory activity. In particular, 8a inhibited Aurora A kinase with an IC50 value of 0.284 μM, whereas 8m inhibited Aurora B kinase with an IC50 value of 0.364 μM.
