118630-46-9

Upstream product

• 10191-60-3 dimethyl N-cyanodithioiminocarbonate 
• 118630-32-3 1-<2-Chloro-4-(dimethylamino)benzyl>piperazine 
• 1424-66-4 2-chloro-4-(dimethylamino)benzaldehyde 

Relevant academic research and scientific papers

5-(1-Piperazinyl)-1H-1,2,4-triazol-3-amines as antihypertensive agents

A series of 5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines was synthesized and screened for antihypertensive and diuretic activity in spontaneously hypertensive rats (SHR). One compound, 5-[4-[(3-chlorophenyl)methyl]-1-piperazinyl]-1H-1,2,4-triazol-3-amine (8), was selected to define the mechanism of its antihypertensive activity. Studies in SHR suggest ganglionic blocking activity. Short-lived antihypertensive activity was observed in conscious renal hypertensive dogs.