1186302-47-5Relevant academic research and scientific papers
Synthesis of a sialic acid containing complex-type n-glycan on a solid support
Tanaka, Katsunori,Fujii, Yohei,Tokimoto, Hiroomi,Mori, Yasutaka,Tanaka, Shin-Ichi,Bao, Guang-Ming,Siwu, Eric R. O.,Nakayabu, Aiko,Fukase, Koichi
supporting information; scheme or table, p. 574 - 580 (2010/04/23)
A new solid-phase synthesis of N-linked glycans featuring 1) highly ste-reoselective b-mannosylation and microfluidic a-sialylation and 2) efficient glycosylation of the N-phenyltrifluoroacetimidate units on JandaJel resin is reported. Reagent concentration effects by a fluorous solvent are effectively applied, and the use of these methods results in the first synthesis of a sialic acid containing complex-type N-glycan on a solid support.
