1186304-19-7Relevant academic research and scientific papers
Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents
Sun, Bin,Li, Lin,Hu, Qing-wen,Zheng, Hong-bo,Tang, Hui,Niu, Huan-min,Yuan, Hui-qing,Lou, Hong-xiang
, p. 186 - 208 (2017)
A series of macrocyclic bisbibenzyls with novel skeletons was designed, synthesized, and evaluated for antiproliferative activity against five anthropic cancer cell lines. Among these novel molecules, compound 47 displayed excellent anticancer activity ag
Dicardinin S derivative as well as preparation method and application thereof
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Paragraph 0097-0101, (2021/10/27)
The invention provides a dibenzylidine S derivative and a preparation method and application thereof, and the derivative has the structure shown I. R1 . R2 Each is independently selected from hydrogen, methyl, (CH). 2 )n R9 , (R C9 . R3 Is H or - (CH)2 )n R9 . R5 . R6 , R7 , R8 Each is independently selected from hydrogen, hydroxy, methyl, halogen, nitro and amino. R9 An amino group and 5-6 元 nitrogen-containing ring. The 5-6 元 nitrogen-containing ring may optionally contain, or not contain, another hetero atom oxygen atom. The amino group and 5-6 元 nitrogen-containing ring may be unsubstituted or selected from C. 1 -5 Alkyl. C1 -5 Haloalkyl, hydroxy, phenyl and substituted C1 -5 Alkoxy or halogen substituted phenyl, R10 S (＝ O)2 At least one substituent in - is substituted. R10 Be selected from C1 -5 Alkyl, 5 - RMB 6 nitrogen-containing rings, n Is 1 or 2. In-flight R1 , R2 Not at the same time methyl.
Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents
Jiang, Juan,Sun, Bin,Wang, Yan-Yan,Cui, Min,Zhang, Li,Cui, Chang-Zhi,Wang, Yan-Feng,Liu, Xi-Gong,Lou, Hong-Xiang
scheme or table, p. 2382 - 2391 (2012/05/05)
Based on the core skeleton of the total synthesized bisbibenzyl marchantin C, riccardin D and plagiochin E, a series of brominated and aminomethylated derivatives of above three bisbibenzyls have been synthesized and their cytotoxic activity against KB, M
