118631-05-3Relevant academic research and scientific papers
Transition Metal Free C-N Bond Forming Dearomatizations and Aryl C-H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent
Farndon, Joshua J.,Ma, Xiaofeng,Bower, John F.
supporting information, p. 14005 - 14008 (2017/10/17)
We outline a simple protocol that accesses directly unprotected secondary amines by intramolecular C-N bond forming dearomatization or aryl C-H amination. The method is dependent on the generation of a potent electrophilic aminating agent released by in situ deprotection of O-Ts activated N-Boc hydroxylamines.
A Simple and Broadly Applicable C?N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents
Ma, Xiaofeng,Farndon, Joshua J.,Young, Tom A.,Fey, Natalie,Bower, John F.
supporting information, p. 14531 - 14535 (2017/10/18)
A C?N bond forming dearomatization protocol with broad scope is outlined. Specifically, bifunctional amino reagents are used for sequential nucleophilic and electrophilic C?N bond formations, with the latter effecting the key dearomatization step. Using t
Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions
Angle, Steven R.,Arnaiz, Damian O.,Boyce, James P.,Frutos, Rogelio P.,Louie, Michael S.,et al.
, p. 6322 - 6337 (2007/10/02)
p-Quinone methides were found to be excellent electrophilic cyclization initiators for the formation of six-membered rings.Cyclizations to form five- and seven-membered rings were also studied.Oxidation of 2,6-disubstituted phenols with Ag2O afforded the
PARA-QUINONE METHIDE INITIATED INTRAMOLECULAR ELECTROPHILIC SUBSTITUTION REACTIONS
Angle, Steven R.,Louie, Michael S.,Mattson, Heather L.,Yang, Wenjin
, p. 1193 - 1196 (2007/10/02)
A study on the reactivity of para-quinone methides in intramolecular cyclization reactions is presented.The para-quinone methides were isolated and completely characterized prior to cyclization.A furan, a pyrrole and a mono-alkyl substituted benzene were
