1186332-19-3Relevant academic research and scientific papers
Discovery of highly potent and selective type I B-Raf kinase inhibitors
Wang, Xiaolun,Berger, Dan M.,Salaski, Edward J.,Torres, Nancy,Hu, Yongbo,Levin, Jeremy I.,Powell, Dennis,Wojciechowicz, Donald,Collins, Karen,Frommer, Eileen
scheme or table, p. 6571 - 6574 (2010/06/12)
A series of pyrazolo[1,5-α]pyrimidine analogs has been prepared and found to be potent and selective B-Raf inhibitors. Molecular modeling suggests they bind to the active conformation of the enzyme.
